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In this issue... *Unsaturated Fat May Reduce Chances of Alzheimer's *Mold in Home May Mean Baby Breathing Problems *Glucosamine Supplements Ok for Diabetics *Low ""Good"" Cholesterol Predicts Death in Elderly *Fat And Breast Cancer Link May Have Been Missed ^^^^^^^^^^^^^^^^^^^^^^^^ Space is limited - Sign up now! ICAK-U.S.A. Fall Regional Meeting October 4-5 2003 Boston MA - Tufts Dental School Please consult the attached registration form for further details.* You will need Adobe® Acrobat® Reader® - a free software for viewing and printing Adobe Portable Document Format (PDF) files on all major hardware and operating system platforms. To download a free copy please visit http://www.adobe.com/products/acrobat/readstep2.html. <<2003TuftsBoston.pdf>> ^^^^^^^^^^^^^^^^^^^^^^^^ CALENDAR OF EVENTS October 4 - 5 2003 2003 ICAK-U.S.A. Fall Regional Meeting In Conjunction with Tufts Dental School Boston MA June 10 - 13 2004 2004 ICAK-U.S.A. Annual Meeting Hyatt Regency Jersey City Jersey City NJ ^^^^^^^^^^^^^^^^^^^^^^ Unsaturated Fat May Reduce Chances of Alzheimer's Weekly consumption of fish as well as other sources of the n-3 fatty acids seems to reduce the likelihood of developing Alzheimer's disease in a large. ""Dietary n-3 polyunsaturated fatty acids improve brain functioning in animal studies but there is limited study of whether this type of fat protects against Alzheimer's disease"" Dr. Martha Clare Morris of the Rush Institute for Healthy Aging Chicago Illinois and colleagues note in an article in the Archives of Neurology. To investigate the scientists studied 815 subjects between the ages of 65 and 94 years who completed a dietary questionnaire and were then followed for an average of 4 years for development of Alzheimer's disease. One hundred thirty-one subjects were found to have Alzheimer's disease during follow-up. Those who consumed fish at least once a week were 60% less likely to develop the disease than those who rarely or never consumed fish. Total intake of n-3 polyunsaturated fatty acids was also associated with a reduced risk of Alzheimer's disease. After adjusting for age subjects in the top fifth of intake had a 70% lower risk compared with those in the lowest fifth of intake. The findings taken in combination with previous results ""suggest that consumption of fish (at least weekly) oil-based salad dressings and nuts may reduce the risk of Alzheimer's disease"" Dr. Morris and colleagues write. SOURCE: Archives of Neurology July 2003. Mold in Home May Mean Baby Breathing Problems Monday July 21 2003 NEW YORK (Reuters Health) - High fungus levels in the home can cause breathing problems even pneumonia for infants new research suggests. Dampness in the basement or other rooms is known to cause breathing problems for children and young adults. The new findings suggest that this may be due to the presence of fungi which thrive in damp locations. However the results also indicate that fungi can be a problem even when the entire house is dry. In a study of 499 children with at least one allergic parent Dr. Diane R. Gold from Harvard University in Boston and colleagues evaluated the effect of domestic fungal levels on breathing problems in the first year of life. The researchers' findings are reported in the American Journal of Respiratory and Critical Care Medicine. After considering other factors such as house dampness and visible mold or mildew the authors found that exposure to high levels of fungi made breathing problems much more likely for infants. For example infants who lived in homes with high levels of one type of fungi--Zygomycetes--were nearly twice as likely to develop problems as other infants. To determine whether a home is likely to cause breathing problems for an infant the authors recommend not only looking for wet spots and mold but also measuring fungi levels. SOURCE: American Journal of Respiratory and Critical Care Medicine July 15 2003 Glucosamine Supplements Ok for Diabetics Monday July 21 2003 NEW YORK (Reuters Health) - Taking glucosamine supplements doesn't affect glucose levels in patients with type 2 diabetes. In fact glucosamine may be safer than some other treatments for painful joints. Glucosamine is increasingly used to treat osteoarthritis. However animal studies have shown that high glucosamine levels can raise blood glucose levels explain the authors of an article in the Archives of Internal Medicine. In the first clinical trial of its kind Dr. Daren Scroggie from Wilford Hall Medical Center at Lackland Air Force Base Texas and associates studied the effects of glucosamine supplementation on glucose control in 34 mostly elderly patients with type 2 diabetes. Over time glucose control changed very little the researchers report whether or not the subjects were taking glucosamine. Only one patient withdrew from the study due to a possible side effect from glucosamine (excessive flatulence) the report indicates and medical therapy did not change during the study. The typical oral doses of glucosamine are around 20 milligrams per kilogram of body weight per day the team explains. By comparison the equivalent doses used in animal studies were much higher ranging from about 3000 milligrams up to 435000 milligrams. ""Since patients with diabetes are at risk for toxic effects from some of the current treatments for osteoarthritis (NSAIDs in particular)"" the authors conclude ""glucosamine may provide a safe alternative treatment for these patients."" SOURCE: Archives of Internal Medicine July 13 2003. Low ""Good"" Cholesterol Predicts Death in Elderly Friday July 18 2003 NEW YORK (Reuters Health) - Low levels of ""good"" cholesterol rather than high levels of ""bad"" cholesterol are associated with an increased risk of death from heart disease and stroke in people who have reached 85 years of age according to a report published in the July 14th issue of the Archives of Internal Medicine. Although high total cholesterol levels are usually tied to adverse outcomes there is evidence that high levels are actually associated with decreased all-cause mortality in the elderly (see Reuters Health reports October 17 1997 and August 2 2001). However the effect of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol levels on mortality in this age group is unclear. Dr. Annelies W. E. Weverling-Rijnsburger from Leiden University in the Netherlands and colleagues measured cholesterol levels in 561 subjects who had recently reached 85 years of age. The subjects were then followed for 4 years. During the study period 152 subjects died and cardiovascular disease was the leading cause the investigators note. Levels of LDL the ""bad"" type of cholesterol did not influence the risk of death from cardiovascular disease the authors found. In contrast low levels HDL the ""good"" cholesterol increased the risk. Subjects with HDL cholesterol levels below 40 mg/dL were twice as likely to die from stroke or heart disease than were subjects with levels above 46 mg/dL. Low levels of HDL as well as LDL cholesterol more than doubled the risk of death from infection the investigators state. High total cholesterol levels were associated with a significantly reduced risk of death from infection. In addition to indicating that that HDL cholesterol but not LDL cholesterol is a predictor of death in the very old the results also suggest that the survival benefits previously seen with high total cholesterol levels may be due to protection against death from infectious disease. Although these laboratory findings are implicated in increased risk rather than the direct cause of death ""it may be argued that increasing HDL cholesterol levels is more advantageous than lowering total cholesterol levels among old people"" the authors conclude. SOURCE: Archives of Internal Medicine 2003. Fat And Breast Cancer Link May Have Been Missed Friday July 18 2003 NEW YORK (Reuters Health) - Contrary to published reports researchers from the UK believe there is an association between high dietary fat and breast cancer. It just hasn't come to light because past studies have been imprecise. The problem is that food frequency questionnaires (FFQs) used to collect information from study patients are ""prone to measurement error"" Dr. Sheila Bingham deputy director of the MRC Dunn Human Nutrition Unit in Cambridge and colleagues suggest in the July 19th issue of The Lancet. ""The degree of error associated with FFQs is considerably larger than previously estimated which could account for the negative findings of...studies of diet and cancer"" they write. The UK team looked at the relationship between breast cancer risk and fat intake using both a FFQ and the more detailed 7-day food diary in roughly 13000 women between 1993 and 1997. By the year 2000 168 cases of breast cancer had occurred. The team matched each case patient to four healthy control subjects. Using the 7-day food-diary estimates subjects with the highest intake of saturated fat had a two-fold rise in breast cancer risk compared with those with the lowest intake they report. In contrast no association between fat intake and breast cancer was evident based on the FFQ. Dr. Bingham and colleagues conclude that these ""preliminary findings suggest that use of the food diary can detect relations between diet and cancer risk within a relatively homogeneous population."" The food diary they add is more expensive to use than the FFQ because the information must be converted into nutrients ""but we have shown that its use is acceptable and feasible in large...studies."" SOUCE: Lancet 2003. Visit our website at www.icakusa.com <http://www.icakusa.com> ^^^^^^^^^^^^^^^^^^^^^^ Although this e-mail and any attachments are believed to be free of any virus or other defect it is the responsibility of the recipient to ensure that this is virus free and no responsibility is accepted by ICAK-U.S.A. for any loss or damage arising from its use.

 
   
 

 
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